The woman was driving north on Foothill Expressway, one mile south of Arastradero Road, at about 2 p.m. when she left the roadway and struck a tree, police spokeswoman Sandra Brown said.
Firefighters at the scene determined the woman was suffering from a traumatic heart attack, according to Battalion Chief Chris Woodard. She was unresponsive with a weak pulse and died as crews worked to extricate her from the wreck.
The Palo Alto Police Department's Special Traffic Accident Reconstruction team is investigating the crash.
Police encouraged anyone with information about the collision to call 650-329-2413."

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